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KMID : 0882420090760030365
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Korean Journal of Medicine
2009 Volume.76 No. 3 p.365 ~ p.369
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Allopurinol-induced agranulocytosis in a patient on peritoneal dialysis
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Kim Jin-Kyung
Lee Young-Ki
Noh Jung-Woo
Ahn Byung-Moo
Kim Jung-Han
Jung Young-Ok
Park Min-Jeong
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Abstract
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Agranulocytosis is a rare, but sometimes dangerous, adverse reaction to allopurinol. We report the unusual case of a 43-year-old man with agranulocytosis, who received allopurinol while undergoing peritoneal dialysis. The bone marrow biopsy indicated that the agranulocytosis was drug-induced. After ceasing all drugs, isolating the patient, and administering granulocyte colony-stimulating factor (G-CSF), the leukocyte count returned to normal. A relationship between allopurinol therapy and agranulocytosis was presumed.
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KEYWORD
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Allopurinol, G-CSF (granulocyte colony-stimulating factor), Agranulocytosis
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